![]() ![]() Place your vote for your favorite in our annual “People’s Choice Award.” Stop by the Chamber Information Table at the Shop Santa’s Village marketplace for information on trees & stores in the decorating contest!ġ0:00AM-4:00PM MAIN STREET STAGE ENTERTAINMENT: Stop by the stage to enjoy eclectic performances by Theatre Workshop of Nantucket, The Boys and Girls Club, Susan J. Stroll through Town to admire the gaily decorated trees and storefronts. Foot of Main Street (Stop & Shop parking lot).ġ0:00AM-3:00PM “PEOPLE’S CHOICE AWARD” STOREFRONT & TREE DECORATING CONTEST. Indulge in the aromas of delectable food and beverages as you chat with friends and survey a variety of handcrafted gifts and merchandise sold by Chamber members and non-profit organizations. Saturday, DecemEventsġ0:00AM-3:00PM SHOP SANTA’S VILLAGE: Meander through the wondrous Christmas Market and celebrate the enchantment of the season. With a focus on shopping locally and celebrating the holiday season, there are plenty of events to spread cheer and good tidings throughout the weekend. Now in its 48th year, Stroll is a community-oriented event sponsored by the Nantucket Island Chamber of Commerce. ![]() Zhu Y, Ma Y, Zu W, Song J, Wang H, Zhong Y, Li H, Zhang Y, Gao Q, Kong B et al. (2020) Identification of N-Phenyl-7 H-pyrrolopyrimidin-4-amine Derivatives as Novel, Potent, and Selective NF-κB Inducing Kinase (NIK) Inhibitors for the Treatment of Psoriasis.Nantucket’s Annual Christmas Stroll 2022 will be underway on December 2, 2022, with festivities planned through December 4, 2022. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.ĩ. ![]() Remsing Rix LL, Rix U, Colinge J, Hantschel O, Bennett KL, Stranzl T, Müller A, Baumgartner C, Valent P, Augustin M et al. (2009) Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells.Ĩ. Kopecky DJ, Hao X, Chen Y, Fu J, Jiao X, Jaen JC, Cardozo MG, Liu J, Wang Z, Walker NP et al. (2008) Identification and optimization of N3,N6-diaryl-1H-pyrazolopyrimidine-3,6-diamines as a novel class of ACK1 inhibitors.ħ. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013) A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.Ħ. Gajiwala KS, Maegley K, Ferre R, He YA, Yu X. (2013) Ack1: activation and regulation by allostery.ĥ. DiMauro EF, Newcomb J, Nunes JJ, Bemis JE, Boucher C, Buchanan JL, Buckner WH, Cheng A, Faust T, Hsieh F et al. (2007) Discovery of 4-amino-5,6-biaryl-furopyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.Ĥ. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity.ģ. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.Ģ. Regulation of clathrin-dependent endocytosisġ. A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase Hotspot SM platform. Reference: 2, 8ĭisplaying the top 10 most potent ligands View all ligands in screen »ĮMD Millipore KinaseProfiler TM screen/Reaction Biology Kinase Hotspot SM screenĪ screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfiler TM service. Quantitative data were derived using DiscoveRx KINOME scan ® platform. NP_001010938 (Hs), NP_058068 (Mm), NP_001008337 (Rn)Ĭrystal structure of Ack1 (TNK2) with compound T74.Ĭrystal structure of Ack1 (TNK2) kinase domain.ĭownload all structure-activity data for this target as a CSV file Inhibitorsĭescription: Inhibitory concentration determined in a Reaction Biology kinase sreening assay.Ī screen of 72 inhibitors against 456 human kinases. ![]()
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